Effect of Cholesterol to Vitamin D3 and Span 60 to Tween 60 Ratios on the Characteristics of Niosomes: Variable Optimization Using Response Surface Methodology (RSM)
Table 5
Estimated coefficients of multiple determinations (R2) for stability using coded values.
Source
Sum of squares
df
Mean square
F-value
value
Model
0.0723
5
0.0145
32.95
0.0008
Significant
A-A
0.0422
1
0.0422
96.14
0.0002
B-B
0.0049
1
0.0049
11.1
0.0207
AB
0
1
0
0.057
0.8208
A2
0.0216
1
0.0216
49.26
0.0009
B2
0.0002
1
0.0002
0.4475
0.5332
Residual
0.0022
5
0.0004
Lack of fit
0.0021
3
0.0007
14.15
0.0667
Not significant
Pure error
0.0001
2
0
Cor total
0.0745
10
R 2: 0.9705; adjusted R2: 0.9411; predicted R2: 0.7970.
