Classification of Alzheimer’s Disease and Mild Cognitive Impairment Based on Cortical and Subcortical Features from MRI T1 Brain Images Utilizing Four Different Types of Datasets

Table 5

Result of four datasets for the subcortical and cortical parts for AD versus HC and EMCI versus LMCI.

AD vs. HC	Classifier	AUC	ACC	SEN	SPEC	PRE	F1	Kappa	Jaccard
ADNI cortical	SVM-RBF	91.67	91.57	81.82	100	100	90	0.8108	0.8333
ADNI subcortical		90.45	90.48	90.91	90	90.91	90.91	0.8091	0.8182
ARWIBO cortical		89.44	89.47	90	88.89	90	90	0.7889	0.8
ARWIBO subcortical		95.45	94.74	100	88.89	90.91	95.24	0.8939	0.8889
NRCD cortical		97.5	97.37	98.18	95.24	96.87	98.18	0.9342	0.9091
NRCD subcortical		95.71	93.42	96.3	86.36	94.55	95.41	0.8379	0.7917
NACC cortical		96.88	95.24	100	83.33	93.75	96.77	0.8772	0.8333
NACC subcortical		92.86	94.56	93.33	100	100	96.55	0.8889	0.8571
EMCI vs. LMCI	Classifier	AUC	ACC	SEN	SPEC	PRE	F1	Kappa	Jaccard
ADNI cortical	SVM-RBF	81.75	81.25	75	87.5	85.71	80	0.725	0.7158
ADNI subcortical		88.89	87.5	77.78	100	100	87.5	0.7538	0.7778
ARWIBO cortical		94.44	93.24	90	100	95.66	94.74	0.8979	0.8889
ARWIBO subcortical		95	94.87	88.89	92.75	100	94.12	0.8889	0.9012
NRCD cortical		92.86	90.91	91.45	100	100	88.89	0.8136	0.8271
NRCD subcortical		96.43	95.45	92.75	100	100	96.45	0.9043	0.9186
NACC cortical		91.67	89.47	87.78	89.57	90.24	87.5	0.7989	0.8133
NACC subcortical		95.83	94.74	92.56	100	100	93.33	0.8902	0.9167