[Retracted] Tranexamic Acid versus Epsilon-Aminocaproic Acid in Total Knee Arthroplasty: A Meta-Analysis
Table 1
Basic characteristics of included literature.
Authors
Year
Country
Type of study
Period of enrollment
Type of surgery
TXA group
EACA group
Age
Female (%)
TXA usage
Age
Female (%)
EACA usage
Camarasa
2006
Spain
RCT
From March 2004 to March 2005
TKA
73 (61–84)
74.3
TXA 10 mg·kg−1 i.v. just before the tourniquet was deflated and 3 h later.
73 (59–80)
87.5
EACA 100 mg kg−1 before tourniquet deflation followed by continuous perfusion (1 g/h−1) during 3 h.
Churchill
2017
USA
Non-RCT
Between April 1, 2012, and December 31, 2014
TKA
65.8 (11.09)
64.3
A single 1 g infusion of TXA or when EACA is used, 5 g infusion done for patients weighing 50 kg or less, or 10 g done for patients weighing more than 50 kg.
63.9 (10.29)
64.3
A single 1 g infusion of TXA or when EACA used, 5 g infusion done for patients weighing 50 kg or less, or 10 g done for patients weighing more than 50 kg.
Boese
2017
USA
RCT
From January 2014 to December 2015
TKA
64.97 ± 9.59
70.4
The regimen for TXA was 1 g in 250 mL of saline solution given over 30 minutes prior to inflating the tourniquet and making the initial incision. A second 1 g in 250 mL of saline solution was infused over 30 minutes beginning at the time of wound closure.
66.12 ± 9.73
74.0
The regimen for EACA was 7 g in 250 mL of saline solution given over 30 minutes just prior to inflating the tourniquet and making the initial incision. A second 7 g of EACA in 250 mL of saline solution was infused over 30 minutes beginning at the time of wound closure.
Bradley
2019
USA
RCT
Between February 2015 and December 2017
TKA
64.7 (60.7–69.6)
68.5
The first dose was given immediately before making the incision and a second dose was given during wound closure. TXA was given as 1 g intravenously in two doses.
65.6 (58.8 to 69.4)
58.3
The first dose was given immediately before making the incision and a second dose was given during wound closure. EACA was given as a 5 g dose in 250 ml of normal saline.
