[Retracted] Reversing Postcardiopulmonary Bypass Associated Cognitive Dysfunction Using k-Opioid Receptor Agonists to Regulate Microglial Polarization via the NLRP3/Caspase-1 Pathway

Figure 3

KORs inhibit post-CPB NLRP3 inflammasome expression in rats’ brain tissue. (a) NLRP3 inflammasome expression level was detected using western blotting. (b) Release of ROS in a different group of rats was visualized with IF (scale bar = 50 μm). (c) Expression levels of preform inflammatory proteins, pro-Caspase-1, pro-IL-1β, and pro-IL-18, were detected with western blotting. (d) Contents of mature IL-1β (pg/ml) and IL-18 (ng/ml) in rats’ brain tissue samples were determined using ELISA. All data in charts were represented as mean ± standard deviation; “” was labeled when the comparative significance between groups ( value) was less than 0.05.

(a)

(b)

(c)

(d)