[Retracted] Reversing Postcardiopulmonary Bypass Associated Cognitive Dysfunction Using k-Opioid Receptor Agonists to Regulate Microglial Polarization via the NLRP3/Caspase-1 Pathway

Figure 4

KORs inhibit cell pyroptosis through mediating cerebral pyrophosphorylation in CPB rats. (a) Expression levels of GSDMD and cleaved GSDMD-N-terminal in rats’ brain tissue samples were quantified with western blotting. (b) Counterstaining of GSDMD and TUNEL (scale bar = 50 μm) was carried out for evaluation of pyrophoric and apoptotic rate, respectively. Relative pyroptotic and apoptotic rates were represented in the form of a bar chart. All data in charts were represented as mean ± standard deviation; “” was labeled when the comparative significance between groups ( value) was less than 0.05.

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