miR-539 Targeting SNAI2 Regulates MMP9 Signaling Pathway and Affects Blood-Brain Barrier Permeability in Cerebrovascular Occlusive Diseases: A Study Based on Head and Neck Ultrasound and CTA

Figure 2

The expression level of miR-539 in the MCAO rat model decreased and affected the permeability of blood-brain barrier. (a) miR-539 expression level in brain tissue around infarction in the sham operation group and MCAO rats. (b) Evans blue leakage level in midbrain tissue of the sham operation group and MCAO rats. (c) Evans blue leakage level in midbrain tissue of rats after lateral ventricle injection of agomiR-539, antagomiR-539, and their corresponding negative control in the MCAO mouse model.