Research Article
Efficacy of Enhanced Cytokine-Induced Killer Cells as an Adjuvant Immunotherapy for Renal Cell Carcinoma: Preclinical and Clinical Studies
Figure 4
Effects of enhanced CIK on nude mice model of xenograft. Mice were injected subcutaneously with ACHN cells 14 days before CIK treatment. Then, mice were randomly divided into four groups and administrated with CIK and PBS as control through intravenous injection or intratumoral injection. (a) The tumors were dissected from the mice and photographed. (b) All tumors collected from the back of each mouse were weighed. (c) The body weight of each mouse was monitored during the treatments. No difference was observed on 0 day and 35 days. (d–f) The effects of CIK treatments on the levels of granzyme B, perforin, and IFN-γ in serum obtained from mice after 21 days of treatments were analyzed by ELISA. CIK treatment group vs. control group (Student’s t-test). The data are represented mean ± S.E.M. of 9 tumors.
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