Review Article

Involvement of Machine Learning Tools in Healthcare Decision Making

Table 1

Applications of deep learning algorithms in computational biology [60].

Deep learning algorithmMedical image analysisProtein structure predictionGenomic sequencing and gene expression analysis

Convolutional neural networkBrain tumour segmentation, knee cartilage segmentation, prediction of semantic descriptions from medical images, segmentation of MR brain images, coronary artery calcium scoring in CT imagesPrediction of protein order/disorder regions, prediction of protein secondary structures, prediction of protein structure properties
Sparse autoencoderOrgan detection in 4D patient data, segmentation of hippocampus from infant brains, histological characterization of healthy skin and healing woundsSequence-based prediction of backbone Cα angles and dihedrals
Deep belief networkSegmentation of left ventricle of the heart from MR data, discrimination of retinal-based diseasesPrediction of protein disorder, prediction of secondary structures, local backbone anglesModelling structural binding preferences and predicting binding sites of RNA-binding proteins, prediction of splice junction at DNA level
Deep neural networkBrain tumour segmentation in MR images, prostate MR segmentation, gland instance segmentationGene expression inference, prediction of enhancer, prediction of splicing patterns in individual tissues and differences in splicing patterns across tissues
Recurrent neural networkClassification of patterns of EEG synchronization for seizure prediction, EEG-based lapse detectionPrediction of protein secondary structure, prediction of protein contact mapPrediction of miRNA precursor and miRNA targets, detection of splice junctions from DNA sequences