Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-κB Pathway

Figure 5

Phenotypic changes and TLR4-NF-κB expression levels of MCAO-induced BV2 cells in vitro. (a) Expression of iNOS, iba-1, Arg-1, TLR-4 and NF-κB of BV2 cells in MCAO group, MCAO + hesperidin group, MCAO + TAK-242 group (TLR-4 inhibitor), and MCAO + BAY group (NF-κB inhibitor). (b) Analysis of the expression levels of inos, iba-1, and Arg-1. (c) Statistical analysis of TLR-4 expression level of BV2 cells in MCAO group, MCAO + hesperidin group, MCAO + TAK-242 group (TLR-4 inhibitor), and MCAO + BAY group (NF-κB inhibitor). (d) Statistical analysis of p-NF-κB expression levels of BV2 cells in MCAO group, MCAO + hesperidin group, MCAO + TAK-242 group (TLR-4 inhibitor), and MCAO + BAY group (NF-κB inhibitor). and .

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