Development of Radiofrequency Ablation Generator and Balloon-Based Catheter for Microendoluminal Thin-Layer Ablation Therapy Using the Rat Duodenum as a Model of Low-Impedance Tissue

Figure 1

Photomicrograph of rat small intestine without achieving targeted tissue destruction in pilot experiments (H&E). (a) With the use of Habib Endo HPB probe: small focal changes with thermocoagulation artifacts (hyperchromatic, elongated nuclei, and hypereosinophilic cytoplasm) limited to the upper part of villi surrounded by vital mucosa. (b) Our balloon-based catheter: vital mucosa of small intestine without detectable changes to epithelium.

(a)

(b)