Development of Radiofrequency Ablation Generator and Balloon-Based Catheter for Microendoluminal Thin-Layer Ablation Therapy Using the Rat Duodenum as a Model of Low-Impedance Tissue

Figure 7

(a) Photomicrograph of rat nonablated proximal small intestine (H&E). (b) Rat proximal small intestine—acute effect of RFA—sample taken immediately after procedure showing ulceration with adjacent fibrin coagulum and intact lamina muscularis mucosae. (c) Rat proximal small intestine—subacute effect of RFA—24 hours after the procedure—transmural necrosis, a sharp transition area between ablated and nonablated mucosa (H&E). (d) Rat proximal small intestine—14 days after the procedure—no structural epithelial changes (H&E).

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