PARP-1 Inhibition Repressed Imbalance of Th17 and Treg Cells in Preterm Rats with Intrauterine Infection-Induced Acute Respiratory Distress Syndrome by Reducing the Expression Level of IL-6

Figure 2

PARP-1 inhibition alleviates lung injury in rats with E.coli-induced ARDS. (a) HE staining was used to perform the histopathological examination of the placenta and uterine wall in rats. (b) HE staining was used to perform the histopathological examination of lung tissues in rats. (c) The wet/dry ratio of the lungs, as well as the numbers of white blood cells and neutrophils, was determined in rats. (d–e) qRT-PCR and western blot were performed to determine the mRNA and protein expression levels of PARP-1, IL-6, IL-17A, and IL-10 in the lung tissues of rats. , , , Vs. control. , , , Vs. E.coli. Each experiment was repeated three times.

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