Tetramethylpyrazine Improves Monocrotaline-Induced Pulmonary Hypertension through the ROS/iNOS/PKG-1 Axis

Figure 1

TMP reversed the process of MCT-induced PH. (a) Representative over view of lift lungs of rats and photomicrographs (magnification: 200×) of H&E-stained of lung sections. Monocrotaline-injection rats (MCT) (B) exhibit serious tissue damage, pulmonary vascular media hypertrophy, and mononuclear cell infiltration compared the control group. TMP-treated rats. (C) showed significant improvements of lung tissue, prevention of pulmonary vascular remodeling, and absorption of infiltration (MCT + TMP). (b) Limited body weight increasing was induced by MCT treated, this limitation was partly broken by TMP treatment. (c) Peak RV systolic pressure developed progressively in MCT-injected rats and TMP treatment prevented development of pulmonary hypertension. (d) Adaptive RV hypertrophy was demonstrated by RV weight: (LV + S) weight ratio in MCT-injection rats. MCT treatment prevented RV hypertrophy. N = 12 per group. Data were mean ± SD, vs. control group. vs. MCT group. PH, pulmonary hypertension.

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