Identifying and Targeting Prediction of the PI3K-AKT Signaling Pathway in Drug-Induced Thrombocytopenia in Infected Patients Receiving Linezolid Therapy: A Network Pharmacology-Based Analysis

Table 1

The related target genes of linezolid-induced thrombocytopenia.

Number	Gene symbol	Number	Gene symbol	Number	Gene symbol
1	CYP3A4	31	ND6	61	TBK1
2	CYP2D6	32	COX3	62	CASP7
3	CYP2C9	33	CYTB	63	AKT1
4	F5	34	TRNS2	64	CASP1
5	POLG	35	F10	65	PABPC1
6	TYMP	36	STAT3	66	FLT1
7	ALB	37	GBA	67	FGFR1
8	IL6	38	MAPK14	68	FLT3
9	COX2	39	PRKDC	69	ACHE
10	PIK3C2A	40	RORC	70	ELANE
11	CYP2C19	41	KDR	71	CDK2
12	IFNG	42	PIK3CB	72	IDO1
13	CCL2	43	CHEK1	73	ERBB2
14	IL10	44	P2RX7	74	EGFR
15	RRM2B	45	SYK	75	MTOR
16	SLC25A4	46	MET	76	AURKB
17	DGUOK	47	LRRK2	77	CDK1
18	FANCI	48	RAF1	78	CDK4
19	MPV17	49	JAK2	79	NAAA
20	TWNK	50	PARP1	80	AURKA
21	TRNM	51	ASAH1	81	ZAP70
22	PPBP	52	CNR2	82	SELE
23	NLRP3	53	PIK3CD	83	KIT
24	TRNL1	54	PIK3CG	84	MAPK8
25	TRNK	55	PIK3CA	85	RAD51
26	TRNF	56	ALOX5
27	CAT	57	PLAT
28	HSPD1	58	KLKB1
29	EPO	59	MAPK1
30	COX1	60	CD38