[Retracted] The Relationship between Antenatal Corticosteroid Administration-to-Delivery Intervals and Neonatal Respiratory Distress Syndrome and Respiratory Support
Table 2
Relationships between ACS-to-birth intervals and neonatal outcomes.
ACS＜24 hn = 264 (37.39%)
ACS 1-2 dn = 83 (11.76%)
ACS 2–7 dn = 292 (41.36%)
ACS>7 dn = 67 (9.49%)
No./total (%)
OR (95% CI)
No./total (%)
OR (95% CI)
No./total (%)
OR (95% CI)
No./total (%)
OR (95% CI)
COR
aOR
COR
aOR
COR
aOR
COR
aOR
Primary outcome
NRDS
174/264 (65.9)
2.3 (1.6–3.3)
1.8 (1.2–2.7)
40/83 (48.2)
1.1 (0.7–1.8)
1.4 (0.8–2.4)
133/292 (45.6)
__
___
29/67 (43.3)
0.9 (0.5–1.6)
0.8 (0.4–1.4)
Secondary outcomes
Neonatal mortality
28/263 (10.6)
3.0 (1.5–6.2)
2.8 (1.1–6.8)
3/83 (3.6)
0.9 (0.3–3.5)
1.5 (0.4–6.1)
11/292 (3.8)
__
___
2/67 (3.0)
0.8 (0.2–3.6)
1.3 (0.2–7.1)
Surfactant use/mechanical ventilation
106/264 (40.2)
2.7 (1.8–3.9)
2.8 (1.7–4.4)
19/83 (22.9)
1.2 (0.7–2.2)
1.6 (0.8–3.1)
58/292 (19.9)
__
___
16/67 (23.9)
1.3 (0.7–2.4)
1.2 (0.6–2.5)
Pulmonary surfactant use
98/264 (37.1)
2.9 (1.9–4.2)
2.7 (1.7–4.4)
15/83 (18.1)
1.1 (0.6–2.0)
1.4 (0.7–2.8)
50/292 (17.1)
__
___
15/67 (22.4)
1.4 (0.7–2.7)
1.3 (0.6–2.7)
Intubation at birth
41/264 (15.5)
2.5 (1.4–4.4)
1.9 (1.0–3.7)
7/83 (8.4)
1.3 (0.5–3.1)
1.6 (0.6–4.3)
20/292 (6.9)
__
___
8/67 (11.9)
1.8 (0.8–4.4)
1.8 (0.7–4.7)
Mechanical ventilation
50/264 (18.9)
2.0 (1.3–3.3)
1.9 (1.1–3.4)
9/83 (10.8)
1.1 (0.5–2.3)
1.3 (0.6–3.1)
30/292 (10.3)
__
___
9/67 (13.4)
1.4 (0.6–3.0)
1.5 (0.6–3.6)
BPD
29/228 (12.7)
1.2 (0.7–2.0)
1.3 (0.7–2.6)
7/76 (9.2)
0.8 (0.3–1.9)
1.4 (0.5–3.7)
30/275 (10.9)
__
___
2/67 (3.1)
0.3 (0.1–1.1)
0.4 (0.1–1.8)
＜0.05 and ＜0.01. COR: crude odds ratio; aOR: adjusted odds ratio; CI: confidence interval; BPD: bronchopulmonary dysplasia; NRDS: newborn respiratory distress syndrome. Univariate and multivariate logistic regression analyses analysed the data. aORs: adjusted for maternal age, birth weight, gestational age at birth, premature rupture of membranes >18 h, mode of delivery, and placenta previa hypertension disorders in pregnancy. The infants exposed to ACS within 2–7 d before birth were regarded as a reference group.
