[Retracted] Growth Differentiation Factor-15 Based ABC (Age, Biomarkers, Clinical History)-AF (Atrial Fibrillation)-Bleeding Risk Score for Elderly Patients with Nonvalvular Atrial Fibrillation

Table 4

Bleeding events and C-index of bleeding risk scores in elderly patients with NVAF, n (%).

Variable		ABC-AF bleeding score^#	HAS-BLED score^#	Z statistic	P-value
Overall (n = 342)
Major bleeding	6 (1.75)	0.72 (0.60–0.84)	0.69 (0.57–0.82)	0.253	0.800
CRNM GIB	57 (16.67)	0.77 (0.70–0.84)	0.79 (0.73–0.85)	0.612	0.541
OB positive	36 (10.53)	0.68 (0.58–0.78)	0.71 (0.61–0.80)	0.513	0.608
Other minor bleeding	32 (9.36)	0.43 (0.34–0.53)	0.34 (0.26–0.41)	1.799	0.072
All bleeding events	131 (38.30)	0.72 (0.66–0.78)	0.71 (0.65–0.77)	0.467	0.641
Patients with OAC (n = 172)
Major bleeding	4 (2.33)	0.77 (0.61–0.92)	0.83 (0.73–0.94)	0.666	0.506
CRNM GIB	22 (12.79)	0.75 (0.65–0.85)	0.69 (0.57–0.82)	0.825	0.410
OB positive	18 (10.47)	0.66 (0.50–0.81)	0.70 (0.55–0.85)	0.455	0.649
Other minor bleeding	21 (12.21)	0.40 (0.30–0.50)	0.48 (0.36–0.59)	1.075	0.283
All bleeding events	65 (37.79)	0.66 (0.58–0.75)	0.69 (0.61–0.78)	0.597	0.551
Patients with non-OAC (n = 170)
Major bleeding	2 (1.18)	0.60 (0.37–0.83)	0.55 (0.38–0.72)	0.207	0.837
CRNM GIB	35 (20.59)	0.81 (0.73–0.89)	0.80 (0.73–0.88)	0.219	0.827
OB positive	18 (10.59)	0.75 (0.65–0.86)	0.67 (0.55–0.79)	1.568	0.117
Other minor bleeding	11 (6.47)	0.25 (0.12–0.38)	0.37 (0.22–0.53)	1.302	0.193
All bleeding events	66 (38.82)	0.75 (0.67–0.82)	0.76 (0.68–0.83)	0.208	0.836

Note: NVAF, nonvalvular atrial fibrillation; MB, major bleeding; CRNM GIB, clinically relevant nonmajor gastrointestinal bleeding; OB positive, fecal occult blood positive; NAT, no antithrombotic treatment; AP, antiplatelet; VKA, vitamin K antagonists; NOACs, non-vitamin K antagonist; ^#C-index (95% CI); with OAC, VKA + NOACs; and Z statistic from DeLong and others, 1988.