[Retracted] Overexpressed RING Finger 44 Correlates with Poor Prognosis in Hepatocellular Carcinoma

Table 5

Univariate and multivariate COX regression analysis for disease-specific survival in the TCGA cohort.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage	370
T1 & T2	277	Reference
T3 & T4	93	2.177 (1.590–2.980)	<0.001	0.372 (0.080–1.732)	0.207
Pathologic stage	349
Stage I & stage II	259	Reference
Stage III & stage IV	90	2.201 (1.591–3.046)	<0.001	4.112 (0.871–19.421)	0.074
Gender	373
Female	121	Reference
Male	252	0.982 (0.721–1.338)	0.909
Age	373
≤60	177	Reference
>60	196	0.960 (0.718–1.284)	0.783
BMI	336
≤25	177	Reference
>25	159	0.936 (0.689–1.272)	0.673
Histologic grade	368
G1 & G2	233	Reference
G3 & G4	135	1.152 (0.853–1.557)	0.355
AFP (ng/ml)	279
≤400	215	Reference
>400	64	1.045 (0.698–1.563)	0.832
Fibrosis Ishak score	214
0	75	Reference
1/2 and 3/4 and 5/6	139	1.363 (0.911–2.039)	0.132
N stage	258
N0	254	Reference
N1	4	1.370 (0.338–5.552)	0.659
M stage	272
M0	268	Reference
M1	4	3.476 (1.091–11.076)	0.035	2.266 (0.632–8.123)	0.209
Weight	345
≤70	184	Reference
>70	161	1.016 (0.750–1.375)	0.920
Height	340
<170	201	Reference
≥170	139	1.252 (0.919–1.706)	0.154
Albumin (g/dl)	299
<3 5	69	Reference
≥3 5	230	0.911 (0.618–1.341)	0.636
Adjacent hepatic tissue inflammation	236
None	118	Reference
Mild & severe	118	1.238 (0.867–1.768)	0.241
Prothrombin time	296
≤4	207	Reference
>4	89	1.100 (0.785–1.541)	0.581
Child–Pugh grade	240
A	218	Reference
B & C	22	1.395 (0.765–2.545)	0.277
Vascular invasion	317
No	208	Reference
Yes	109	1.676 (1.196–2.348)	0.003	1.332 (0.885–2.006)	0.169
RNF44	373
Low	187	Reference
High	186	1.511 (1.129–2.022)	0.006	1.483 (1.003–2.195)	0.049

Note. The stages were graded according to AJCC7. RNF44: RING Finger protein 44; AJCC7: American Joint Committee on Cancer 7th edition. Bold means statistically significant.