Let-7a Targeting TNFAPI3 Promotes Vascular Endothelial Cell Apoptosis of Pediatric Patients with Henoch–Schönlein Purpura via NF-κB Signaling Pathway

Figure 1

The expression of let-7a and TNFAIP3 in HSP patients. The expressions of let-7a (a) and TNFAIP3 (b) in skin tissues were detected by qRT-PCR analysis. Let-7a was significantly elevated in HSP samples, and TNFAIP3 was downregulated in controls. (c) Negative correlation between let-7a and TNFAIP3 expression in skin tissues by Pearson correlation analysis. (d) The expression of let-7a was detected in HSP patients with different degrees of vessel fibrinoid necrosis. Let-7a expression was upregulated with the increased number of fibrinoid necrosis in HSP patients. (e) Positive correlation between let-7a expression and serum IgA level in HSP patients by Pearson correlation analysis. , . Ns, no significant difference.

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