Let-7a Targeting TNFAPI3 Promotes Vascular Endothelial Cell Apoptosis of Pediatric Patients with Henoch–Schönlein Purpura via NF-κB Signaling Pathway

Figure 2

Let-7a affects apoptosis of HSP serum-induced vascular endothelial cell in vitro. Cell viability (a) and let-7a expression (b) were detected in HUVECs treated with 10% HSP serum for 12, 24, 48, and 72 (h) , , , compared with control. Ns, no significant difference. HUVECs were transfected with let-7a/NC inhibitor and exposed to HSP serum for 48, and (h) then, transfection efficiency (c), cell viability (d), cell apoptosis rate (e), and apoptosis-related proteins (f) were evaluated. , , . Ns, no significant difference.

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