Let-7a Targeting TNFAPI3 Promotes Vascular Endothelial Cell Apoptosis of Pediatric Patients with Henoch–Schönlein Purpura via NF-κB Signaling Pathway

Figure 4

NF-κB pathway was involved with let-7a modulated vascular endothelial cell apoptosis. (a) The expression of NF-κB pathway-related proteins was detected by western blot. (b) p65 nuclear translocation was detected by immunohistochemistry. (c) Cell viability was detected after cells were treated with let-7a inhibitor, or/and TNFAIP3 siRNA or and NF-κB pathway inhibitor PDTC. (d) Cell apoptosis was measured by flow cytometry. (e) The apoptosis-related proteins were detected by western blot. , , . Ns, no significant difference.

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