Analysis of Multiple Vitamins Serum Levels and Disease-Related Factors in Children with Acute Leukemia
Table 7
Analysis of factors influencing different treatment regimens in children with acute leukemia.
Indicators
CAML group (n = 15)
MTX group (n = 9)
VDLP group (n = 38)
Other groups (n = 45)
F/X2
Age
6.22 ± 4.46
4.93 ± 2.67
5.18 ± 2.95
6.92 ± 3.63
2.483
0.065
BMI
16.54 ± 3.28
16.24 ± 2.51
16.59 ± 2.90
16.45 ± 2.77
0.043
0.988
Gender
Male
7 (46.67)
4 (44.44)
23 (60.53)
27 (60.00)
1.590
0.662
Female
8 (53.33)
5 (55.55)
15 (39.47)
18 (40.00)
Diagnostic results
AML
0
1 (11.11)
0
22 (48.89)
35.098
<0.001
ALL
15 (100.00)
8 (88.89)
38 (100.0)
23 (51.11)
Immunophenotype
B
15 (100.00)
5 (55.55)
37 (97.37)
19 (42.22)
47.056
<0.001
T
0
3 (33.33)
1 (2.63)
5 (11.11)
AML
0
1 (11.11)
0 (2.9)
21 (46.67)
Liver function
Abnormal
2 (26.67)
3 (33.33)
9 (23.68)
15 (33.33)
2.908
0.406
Normal
13 (73.33)
6 (66.67)
29 (76.32)
29 (64.44)
Renal function
Abnormal
6 (40.00)
2 (22.22)
6 (15.79)
5 (11.11)
6.666
0.083
Normal
9 (60.0)
7 (77.78)
32 (84.21)
40 (88.89)
Icterus
Yes
1 (6.67)
1 (11.11)
1 (2.63)
5 (11.11)
2.335
0.506
No
14 (93.33)
8 (88.89)
37 (97.37)
40 (88.89)
Biochemical indicator
Alanine aminotransferase (ALT, mmol/L)
20.68 ± 14.95
40.89 ± 23.79
47.79 ± 104.97
37.56 ± 55.13
0.502
0.682
Aspartate aminotransferase (AST, mmol/L)
22.66 ± 5.71
37.66 ± 14.25
33.11 ± 39.72
40.75 ± 42.94
0.953
0.418
Lactate dehydrogenase (LD, U/L)
215.33 ± 44.06
235.67 ± 41.50
374.24 ± 307.76
601.95 ± 1473.89
0.858
0.465
Hydroxybutyric dehydrogenase (HBDH, U/L
164.67 ± 36.99
2.36 ± 3.30
293.61 ± 223.21
414.68 ± 974.95
0.763
0.517
Serological indicators
White blood cell count (WBC, 109/L)
2.27 ± 1.75
4.32 ± 1.33
10.30 ± 18.23
12.25 ± 22.29
1.394
0.249
Neutrophils (N, 109/L)
1.46 ± 1.22
3.22 ± 1.61
1.57 ± 1.74
4.61 ± 6.59
3.846
0.012
Hemoglobin (Hb, g/L)
9.09 ± 1.67
98.56 ± 16.30
84.68 ± 20.73
94.00 ± 23.38
1.807
0.151
Platelet (PLT, 109/L
2.26 ± 1.09
171.11 ± 88.49
171.00 ± 133.53
126.84 ± 94.98
3.233
0.025
Lymphocyte (L, 109/L)
0.62 ± 0.46
0.85 ± 0.42
7.53 ± 14.78
3.80 ± 10.06
1.961
0.124
C-reactive protein (CRP, mg/L)
7.67 ± 17.66
5.60 ± 11.21
6.99 ± 26.19
10.43 ± 20.52
0.225
0.879
Activated partial thromboplastin time (APTT, s)
35.31 ± 9.31
31.26 ± 4.89
26.63 ± 3.54
31.96 ± 5.88
10.267
<0.001
Troponin (Tn)
8.92 ± 4.17
13.88 ± 13.80
5.02 ± 2.91
10.43 ± 10.97
1.370
0.261
Vitamin level
Vitamin A (VA, μmol/L)
0.81 ± 0.20
0.79 ± 0.16
0.70 ± 0.27
0.73 ± 0.18
1.173
0.324
Vitamin B1 (VB1, nmol/L)
101.03 ± 13.23
100.91 ± 14.64
95.16 ± 11.22
101.85 ± 12.08
2.279
0.084
Vitamin B2 (VB2, μg/L)
5.29 ± 0.88
4.73 ± 0.66
5.53 ± 1.68
5.90 ± 2.28
1.247
0.297
Vitamin B6 (VB6, nmol/L)
32.83 ± 13.74
29.82 ± 12.24
40.03 ± 16.67
29.72 ± 12.68
3.854
0.012
Vitamin B9 (VB9, nmol/L)
2.06 ± 5.36
21.76 ± 7.45
18.53 ± 5.28
20.14 ± 5.93
1.113
0.347
Vitamin B12 (VB12, pg/mL)
434.05 ± 54.62
435.39 ± 74.77
515.39 ± 98.76
470.93 ± 87.31
4.415
0.006
Vitamin C (VC, μmol/L)
40.16 ± 7.20
39.71 ± 3.98
38.25 ± 5.80
38.67 ± 5.04
0.507
0.204
Vitamin D (VD, nmol/L)
50.22 ± 23.74
39.16 ± 10.24
37.98 ± 13.87
43.05 ± 19.46
1.954
0.678
Vitamin E (VE, μg/mL)
10.49 ± 0.48
10.60 ± 0.59
10.78 ± 0.86
10.70 ± 0.75
1.846
0.144
Data were mean ± SD or n (%). Missing = 13. AML, acute myeloid leukemia; BMI, body mass index; CAML, cyclophosphamide + cytosine arabinoside+6-mercaptopurine + pegaspargase; MTX, methotrexate; VDLP, vindesine + daunomycin + L-asparaginasum + prednisone. The value with P > 0.05 is indicated in bold.
