Research Article
[Retracted] Differential Prognostic Analysis of Higher and Lower PEEP in ARDS Patients: Systematic Review and Meta-Analysis
Table 2
Higher PEEP compared lower PEEP in ARDS patients with different clinical outcomes of interest.
| | Certainty assessment | No. of patients | Effect | Certainty | Importance | | No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Higher PEEP | Lower PEEP | Relative (95% CI) | Absolute (95% CI) |
| | Hospital mortality | | 8 | Randomized trials | Not serious | Not serious | Not serious | Not serious | Strong association | 766/1827 (41.9%) | 805/1856 (43.4%) | RR 0.97 (0.89 to 1.04) | 13 fewer per 1,000 (from 48 fewer to 17 more) | High | Critical |
| | 28-day mortality | | 8 | Randomized trials | Not serious | Not serious | Not serious | Not serious | None | 576/1567 (36.8%) | 610/1601 (38.1%) | RR 0.96 (0.88 to 1.05) | 15 fewer per 1,000 (from 46 fewer to 19 more) | High | Critical |
| | ICU mortality | | 6 | Randomized trials | Not serious | Not serious | Not serious | Not serious | None | 514/1186 (43.3%) | 549/1219 (45.0%) | RR 0.96 (0.88 to 1.04) | 18 fewer per 1,000 (from 54 fewer to 18 more) | High | Critical |
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CI: confidence interval; RR: risk ratio.
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