Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model

Table 6

Effect of total glucosides of Xiebai on pathological changes of the hypothalamus in chronic depression model rats.

Group	Number of animals	Dose (mg·kg^−1)	—	+	++	+++
Blank group	10	—	10	0	0	0	<0.01
Model group	10	—	0	0	2	8
Fluoxetine hydrochloride group	10	6.6	3	6	1	0	<0.01
High-dose Xiebai total glycosides group	10	200	7	2	1	0	<0.01
Medium-dose Xiebai total glycosides group	10	100	2	7	1	0	<0.01
Low-dose Xiebai total glycosides group	10	50	1	7	2	0	<0.01

Note. “—”: nerve cells have a clear structure and no abnormality; “+”: nerve cells shrink in size, and cytoplasm is less; “++”: nerve cells shrink in size, the cytoplasm is less, and cytoplasmic Nissl bodies disappear; “+++”: nerve cells are reduced in size, with less cytoplasm and pyknosis, or have a neurotic phenomenon.