[Retracted] METTL3 Accelerates Breast Cancer Progression via Regulating EZH2 m⁶A Modification

Figure 4

METTL3 downregulated E-cadherin through EZH2 recruitment and thus promoted malignancy of BCa. (a) qRT-PCR detected the METTL3 mRNA levels; (b) western blotting determined the METTL3 protein in MCF-7 cells transfected with si-EZH2; (c) qRT-PCR detected E-cadherin mRNA levels; (d) western blotting determined E-cadherin protein in MCF-7 cells transfected with si-EZH2; (e) E-cadherin enrichment in anti-IgG, anti-EZH2, or anti-H3K27me3; (f) protein levels of E-cadherin, N-cadherin, and vimentin in MCF-7 cells transfected with si-METTL3 or si-METTL3 + si-E-cadherin; (g) migration and invasion in MCF-7 cells transfected with si-METTL3 or si-METTL3 + si-E-cadherin.

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