Research Article

A Nomogram for Predicting Cardiovascular Diseases in Chronic Obstructive Pulmonary Disease Patients

Table 1

Comparison of the characteristics between the COPD patients with CVDs and without CVDs.

VariableTotal (n = 1022)CVDStatistical magnitude
No (n = 752)Yes (n = 270)

Gender, n (%)χ 2 = 0.0120.912
Male635 (62.13)468 (62.23)167 (61.85)
Female387 (37.87)284 (37.77)103 (38.15)
Age, mean ± SD61.92 ± 12.8760.34 ± 13.2066.33 ± 10.72t = -7.38<0.001
Race, n (%)χ 2 = 1.3230.516
Non-Hispanic White699 (68.40)507 (67.42)192 (71.11)
Non-Hispanic Black170 (16.63)130 (17.29)40 (14.81)
Other race153 (14.97)115 (15.29)38 (14.07)
Education level, n (%)Z = -2.1390.032
Under 12th grade278 (27.20)191 (25.40)87 (32.22)
High school grad/GED274 (26.81)203 (26.99)71 (26.30)
Some college or above470 (45.99)358 (47.61)112 (41.48)
Marital status, n (%)χ 2 = 0.6340.426
Married536 (52.45)400 (53.19)136 (50.37)
Others486 (47.55)352 (46.81)134 (49.63)
Annual family income, n (%)χ 2 = 7.5990.006
<20000$318 (31.12)216 (28.72)102 (37.78)
≥20000$704 (68.88)536 (71.28)168 (62.22)
Smoking, n (%)χ 2 = 8.8170.003
Yes823 (80.53)589 (78.32)234 (86.67)
No199 (19.47)163 (21.68)36 (13.33)
Overweight, n (%)χ 2 = 25.203<0.001
Yes385 (37.67)249 (33.11)136 (50.37)
No637 (62.33)503 (66.89)134 (49.63)
A history of blood transfusion, n (%)χ 2 = 48.405<0.001
Yes237 (23.19)133 (17.69)104 (38.52)
No785 (76.81)619 (82.31)166 (61.48)
A history of heart disease in close relatives, n (%)χ 2 = 31.967<0.001
Yes211 (20.65)123 (16.36)88 (32.59)
No811 (79.35)629 (83.64)182 (67.41)
WBC, mean ± SD7.75 ± 2.257.62 ± 2.228.08 ± 2.30t = -2.890.004
MONO, mean ± SD8.31 ± 2.528.16 ± 2.528.75 ± 2.49t = -3.30<0.001
NEUT, M (Q1, Q3)4.50 (4.10,5.60)4.40 (4.00, 5.60)4.80 (4.40, 6.00)Z = 3.2890.001
PLT, mean ± SD240.39 ± 65.65244.59 ± 65.97228.70 ± 63.42t = 3.43<0.001
LYM, M (Q1, Q3)2.00 (1.80, 2.50)2.00 (1.90, 2.50)1.90 (1.70, 2.40)Z = -2.5760.010
NLR, M (Q1, Q3)2.26 (2.00, 3.11)2.19 (1.97, 2.91)2.55 (2.31, 3.57)Z = 4.577<0.001
PLR, M (Q1, Q3)118.27 (109.05, 154.74)119.18 (110.00, 155.19)114.49 (106.50, 152.14)Z = -0.3710.711

COPD: chronic obstructive pulmonary disease, WBC: white blood cell, MONO: monocyte, NEUT: neutrophil, PLT: platelet, LYM: lymphocyte, NLR: neutrophil/lymphocyte ratio, PLR: platelet/lymphocyte ratio, CVD: cardiovascular disease, GED: general equivalent diploma or equivalent.