The Role of Osthole on TGF-<i>β</i>-Induced Lung Epithelium Apoptosis Injury and Epithelial-Mesenchymal Transition-Mediated Airway Remodeling in Pediatric Asthma

<div>Osthole attenuated epithelial injury and EMT in OVA-exposed mice. (a) Histopathologic examination of lung bronchial tissues evaluated by hematoxylin and eosin staining (upper panel 200x and lower panel 400x). (b) Masson’s staining performed to show the change in tissue fiber around the bronchus (400x). (c) The expression of E-cadherin, N-cadherin, and Snail in lung tissues detected by Western blot. (d) The expressions of TGF-<i>β</i>1, phosphorylated level of Smad2 and Smad3, and total Smad2/3 in lung tissues measured by Western blot. (e) The change in protein levels of Bax, Bcl-2, and cleaved-caspase3 in lung tissues examined by Western blot. 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Journal of Healthcare Engineering

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Figure 4

Figure 4: The Role of Osthole on TGF-<i>β</i>-Induced Lung Epithelium Apoptosis Injury and Epithelial-Mesenchymal Transition-Mediated Airway Remodeling in Pediatric Asthma 

Figure 4 | The Role of Osthole on TGF-β-Induced Lung Epithelium Apoptosis Injury and Epithelial-Mesenchymal Transition-Mediated Airway Remodeling in Pediatric Asthma 