Machine Learning-Based Prediction Model of Preterm Birth Using Electronic Health Record

Table 2

Prenatal testing of pregnant women before 27 weeks of gestation between PTB and control group.

Variables			Control (4775)	Case (4775)	t/chi
Physical examination	Waist size, cm		82.68 ± 14.19	83.30 ± 13.74	−2.17	0.030
	Fundal height, cm		20.57 ± 3.62	20.90 ± 3.84	−4.33	<0.001
	SBP, mmHg		112.09 ± 10.26	113.34 ± 10.44	−5.86	<0.001
	DBP, mmHg		69.47 ± 7.72	70.71 ± 16.09	−4.82	<0.001
	FHR, times/min		145.50 ± 3.05	146.46 ± 17.27	−3.78	<0.001
	Weight, kg		63.16 ± 9.15	63.04 ± 9.39	0.60	0.549
	Edema	No	4759 (1.00)	4747 (0.99)	2.76	0.096
		Yes	16 (0.00)	28 (0.01)
Blood test	BG	A	1238 (0.26)	1063 (0.22)	128.27	<0.001
		B	1571 (0.33)	2106 (0.44)
		AB	484 (0.10)	417 (0.09)
		O	1482 (0.31)	1189 (0.25)
	Blood RH	Ne	24 (0.01)	15 (0.00)	1.65	0.199
		Po	4751 (0.99)	4760 (1.00)
	ALB, g/L		41.24 ± 3.46	41.45 ± 2.75	−3.20	0.001
	ALT, U/L		20.65 ± 14.05	21.02 ± 13.69	−1.28	0.199
	AST, U/L		20.91 ± 7.81	22.14 ± 7.72	−7.74	<0.001
	Glu, mmol/L		4.57 [4.25, 4.93]	4.56 [4.23, 4.72]		<0.001
	Ca, mmol/L		2.30 ± 0.14	2.31 ± 0.12	−1.36	0.174
	Cr, umol/L		50.86 ± 7.61	51.17 ± 8.25	−1.92	0.055
	DB, umol/L		1.72 [1.10, 2.30]	1.74 [1.43, 1.90]		0.594
	TSI, umol/L		17.44 ± 3.33	17.60 ± 2.63	−2.61	0.009
	GLOB, g/L		27.28 ± 3.32	27.24 ± 2.43	0.73	0.466
	Mg, mmol/L		0.87 ± 0.13	0.88 ± 0.09	−4.43	<0.001
	IP, mmol/L		1.25 ± 0.15	1.25 ± 0.12	−1.61	0.108
	TBA, umol/L		3.83 [2.90, 5.10]	4.90 [3.32, 5.01]		<0.001
	TB, umol/L		11.28 ± 3.53	11.18 ± 2.64	1.67	0.095
	CHOL, mmol/L		4.78 ± 0.73	4.80 ± 0.38	−1.66	0.096
	TP, g/L		68.76 ± 4.84	68.78 ± 3.55	−0.22	0.829
	TG, mmol/L		1.52 ± 0.54	1.58 ± 0.41	−6.57	<0.001
	Urea, mmol/L		2.80 [2.38, 3.28]	2.84 [2.40, 3.10]		0.002
	UA, umol/L		199.75 ± 40.26	198.22 ± 39.37	1.88	0.060
	BA, 10e9/L		0.01 ± 0.03	0.01 ± 0.05	−1.01	0.314
	Plt, 10e9/L		220.31 ± 48.25	224.52 ± 48.60	−4.25	<0.001
	EOS, 10e9/L		0.09 ± 0.09	0.09 ± 0.07	0.43	0.665
	Hb, g/L		117.98 ± 8.56	117.69 ± 8.59	1.62	0.105
	MID, 10e9/L		0.55 ± 0.10	0.56 ± 0.12	−4.51	<0.001
	LY, 10e9/L		1.72 ± 0.40	1.75 ± 0.41	−2.92	0.004
	MCH, pg		31.49 ± 1.91	31.33 ± 1.85	4.15	<0.001
	MCHC, g/L		344.87 ± 10.25	343.39 ± 10.52	6.95	<0.001
	MCV, fL		91.31 ± 4.72	91.24 ± 4.50	0.76	0.445
	MO, 10e9/L		0.53 ± 0.14	0.54 ± 0.14	−4.33	<0.001
	MPV, fL		8.58 ± 1.10	8.60 ± 1.09	−1.07	0.283
	NE, 10e9/L		7.23 ± 1.69	7.36 ± 1.72	−3.60	<0.001
	P-LCR, %		0.23 ± 0.05	0.23 ± 0.05	5.83	<0.001
	HCT, %		0.34 ± 0.02	0.35 ± 0.25	−1.18	0.238
	PCT, %		0.19 ± 0.04	0.19 ± 0.03	−0.23	0.819
	PDW, %		15.16 ± 2.25	14.83 ± 2.51	6.75	<0.001
	RDW-CV, %		0.16 ± 0.51	0.16 ± 0.35	0.81	0.416
	RDW-SD, fL		42.84 ± 2.46	43.45 ± 2.12	−13.07	<0.001
	RBC, 10e12L		3.76 ± 0.31	3.77 ± 0.32	−1.51	0.131
	WBC, 10e9/L		9.58 ± 1.93	9.74 ± 1.97	−3.93	<0.001
Urine test strip	Urine pH		6.67 ± 0.46	6.73 ± 0.46	−6.77	<0.001
	USG		1.02 ± 0.01	1.02 ± 0.01	4.96	<0.001
	BIL	Ne	4737 (0.99)	4749 (0.99)	1.90	0.168
		Po	38 (0.01)	26 (0.01)
	Glycosuria	Ne	3780 (0.79)	3820 (0.80)	0.98	0.322
		Po	995 (0.21)	955 (0.20)
	KET	Ne	4593 (0.96)	4589 (0.96)	0.03	0.873
		Po	182 (0.04)	186 (0.04)
	Nitrituria	Ne	4728 (0.99)	4740 (0.99)	1.49	0.222
		Po	47 (0.01)	35 (0.01)
	Blood	Ne	4322 (0.91)	4397 (0.92)	7.22	0.007
		Po	453 (0.09)	378 (0.08)
	Proteinuria	Ne	4729 (0.99)	4698 (0.98)	7.41	0.006
		Po	46 (0.01)	77 (0.02)
	Bilirubinuria	Ne	4758 (1.00)	4755 (1.00)	0.11	0.742
		Po	17 (0.00)	20 (0.00)
	Urine WBC	Ne	3490 (0.73)	3475 (0.73)	0.10	0.747
		Po	1285 (0.27)	1300 (0.27)
Gynecological examination	BV	Ne	4678 (0.98)	4719 (0.99)	10.63	0.001
		Po	97 (0.02)	56 (0.01)
	CDV	1	854 (0.18)	975 (0.20)	60.20	<0.001
		2	2904 (0.61)	3066 (0.64)
		3	845 (0.18)	590 (0.12)
		4	172 (0.04)	144 (0.03)
	VYI	Ne	4499 (0.94)	4549 (0.95)	5.05	0.025
		Po	276 (0.06)	226 (0.05)

ALB: serum albumin; ALT: alanine transaminase; AST: aspartate transaminase; BA: basophil granulocytes; BG: blood group; BIL: urine bilirubin; Blood RH: blood RH; BV: bacterial vaginosis; Ca: total calcium; CDV: cleaning degree of vagina, The higher the value, the worse the cleanliness; CHOL: total cholesterol; Cr: creatinine; DB: direct bilirubin; DBP: diastolic blood pressure; EOS: eosinophil granulocytes; FHR: fetal heart rate; GLOB: globulins; Glu: plasma glucose (fasting); Hb: hemoglobin; HCT: hematocrit; IP: serum inorganic phosphorus; KET: urine ketone bodies; LY: lymphocytes; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean cell volume; Mg: magnesium; MID: intermediate cell; MO: monocytes; MPV: mean platelet volume; NE: neutrophil granulocytes; PCT: plateletcrit; PDW: platelet distribution width; P-LCR: mean platelet volume; Plt: platelet count; RBC: red blood cells; RDW-CV: red blood cell distribution width-CV; RDW-SD: red blood cell distribution width-CV; SBP: systolic blood pressure; TB: total bilirubin; TBA: total biliary acid; TG: triglycerides; TP: total protein; TSI: total serum iron; UA: uric acid; Urea: urea; Urine WBC: urine white blood cell; USG: urine specific gravity; VYI: vaginal yeast infection; WBC: white blood cell count; PTB: preterm birth. Variables that are not normally distributed were expressed as p50 [p25, p75].