Worms and the Treatment of Inflammatory Bowel Disease: Are Molecules the Answer?
Figure 2
Effect of Schistosoma mansoni soluble worm
proteins (SmSWPs) and Ancylostoma caninum excretory/secretory
products (AcESPs) on myeloperoxidase (MPO) activity. MPO activity was measured to
monitor the degree of myeloid cell infiltration in the colon. Data are presented as
units MPO per gram of colon tissue and 1 unit equals the amount of MPO necessary
to degrade 1 mol of H2O2 to H2O per minute at 25°C. TNBS-induced colitis caused a significant increase in MPO activity compared to control mice treated with phosphate-buffered saline (PBS). Intraperitoneal injection of
helminth-derived products significantly ameliorated inflammation as shown by the significant decrease in MPO activity. Treatment of control mice with SmSWP or AcESP had no effect (data not shown). *, significantly different from contol PBS; ,
significantly different from TNBS-PBS; two way ANOVA, [77].
