Methotrexate and Cyclosporine Treatments Modify the Activities of Dipeptidyl Peptidase IV and Prolyl Oligopeptidase in Murine Macrophages
Figure 1
Effect of
Z-pro-prolinal on soluble prolyl oligopeptidase activity of
thioglycollate-elicited murine macrophages. The values (means ± SEM from 5 animals) were recorded in
triplicate as the percentage of inhibition relative to control reactions
(enzyme activity = 100%, percentage of inhibition = 0) which run simultaneously in
absence of Z-pro-prolinal. All concentrations of Z-pro-prolinal produced lower
levels of enzyme activity when compared to the control (unpaired two-sided
Student's t-test, ).
in comparison to M or M; in comparison to all other concentrations
of Z-pro-prolinal (analysis of variance, ANOVA, followed by SNK test).
