Renal Failure Associated with APECED and Terminal 4q Deletion: Evidence of Autoimmune Nephropathy

Figure 2

Superficial esophageal mucosa ((a),(b)) invaded by candidal psudohyphae. Grocott-Methenamine silver (original magnification 200x (a)/400x (b)). Renal biopsy ((c), (d), (e)) shows ischemic glomerular tuft with thick and wrinkled basement membrane (PAS stain 40x) (c) and extensive tubular loss with replacement by fibrosis (Masson trichrome stain 40x) (d). The interstitium shows lymphocytes and plasma cells (arrows) (H&E 40x) (e). The immunofluorescence staining for C3 and C1q is shown in (f) and (g), respectively.

(a)

(b)

(c)

(d)

(e)

(f)

(g)