Hepatitis C Virus Induces Regulatory T Cells by Naturally Occurring Viral Variants to Suppress T Cell Responses
Figure 4
PBMC proliferative responses to NS3358–375 peptide variants. (a) HCV subject P.B3019 PBMC incubated for 3 h with peptide variants at 1 μM then with the addition of 1 μM wild-type peptide NS3358–375 where indicated. On Day 4, proliferating cells were labeled with 1 μCi 3H-TdR for the final 16 h of incubation, and cells were harvested for measurement of 3H-TdR incorporation on Day 5. Results are shown in mean counts per minute (CPM) +/- standard error of at least triplicate cultures. * as determined by Student’s t-test. **. Results are representative of greater than 10 experiments.
