Hepatitis C Virus Induces Regulatory T Cells by Naturally Occurring Viral Variants to Suppress T Cell Responses

Figure 7

DRB1*1501 MHC class II variant and cognate tetramers are able to bind to CD4⁺ T-cells from multiple patients. PBMCs from a noninfected (P1163), chronic (P.B3019), and resolved (JVP008) were individually stained with DR15 MHC class II tetramers (2 μg/ml). P.1163 is a noninfected DR15 subject and was used as a control to test for nonspecific labeling of each DR15 tetramer (first column). DR15-CLIP-APC and -PE tetramers were used as a control for each experiment (bottom two rows).