Research Article

Hepatitis C Virus Induces Regulatory T Cells by Naturally Occurring Viral Variants to Suppress T Cell Responses

Table 1

HCV and HLA genotypes of HCV subjects. HCV and HLA types of chronic and resolved subjects used in this study. All subject’s PBMC were incubated with recombinant NS3 protein (rNS3) in a dose-dependent manner using a proliferation assay to detect T cell responses. All subjects were screened for HCV RNA by quantitative PCR. In the case of resolved subjects, in which they had no detectable viral load, a RIBA was performed to screen for HCV antibodies. *subjects used for T cell proliferation assay in Figure 1.

Subject IDHCV statusGenotypeHLA-DRAB

*RLM 037R1,15+
*KML044R9,15+
*ZSS035R1,15+
*LEC028R1,8+
*KTJ010R1,15+
*BPB026R3,15+
*DRB012R7,7+
*JVP008R15,15+
JPZ061R4,4+
PH1127R13,15+
PH1079R4,15+
*AJG066C1A1,8ND
*KRW002C1A8,14ND
*MH065C1A14,15ND
*P.B3019C1A15,7ND
*NLM049C1A11,13ND
*CER014C1A7,13ND
*DRB051C1A1,13ND
*SSB007C1A7,13ND
RLW027C1A4,15ND
P.1022NI8,10
P.1163NI1,15
P.1078NI9,13
P.1127NI5,6