Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis

Table 2

Glomerular targets for anti-double-stranded (ds)-DNA antibodies [11, 12].

Molecules that directly cross-react with anti-dsDNA antibodies	Cell type/glomerular matrix
Alpha-actinin	Mesangial cells
Annexin A2	Mesangial cells, epithelial cells
Ribosomal P protein	Mesangial cells, endothelial cells
Alpha-enolase	Mesangial cells, epithelial cells
Laminin	Glomerular matrix
Fibronectin	Glomerular matrix
Collagen	Glomerular matrix
Heparan sulfate	Glomerular matrix
Hyaluronic acid	Glomerular matrix