Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"></td><td align="center">Granulocytic MDSCs</td><td align="center">Monocytic MDSCs</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Murine</td><td align="center">CD11b<sup>+</sup> Ly6G<sup>+</sup> Ly6<svg height="17.012501" id="M1" style="vertical-align:-0.20473pt" version="1.1" viewbox="0 0 29.0875 17.012501" width="29.0875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q0 -140 73.5 -227.5t188.5 -87.5q73 0 119.5 37.5t86.5 116.5z" id="x43"></path></g>
<g transform="matrix(.012,0,0,-.012,11.363,8.538)"><path d="M238 0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" id="x6C"></path></g><g transform="matrix(.012,0,0,-.012,14.373,8.538)"><path d="M257 449q92 0 154 -65t62 -158q0 -112 -67 -175t-150 -63q-98 0 -158.5 66.5t-60.5 154.5q0 59 21 106.5t54.5 75.5t71 43t73.5 15zM244 416q-48 0 -81 -47t-33 -128q0 -96 38 -158t99 -62q51 0 82 43.5t31 139.5q0 91 -36 151.5t-100 60.5z" id="x6F"></path></g><g transform="matrix(.012,0,0,-.012,20.263,8.538)"><path d="M696 437v-26q-37 -5 -50.5 -18.5t-28.5 -55.5q-36 -96 -120 -348h-29l-69.5 178.5l-52.5 132.5l-54.5 -141l-64.5 -170h-28q-71 229 -116 357q-13 39 -25.5 49.5t-48.5 15.5v26h207v-26q-45 -7 -53.5 -17t2.5 -44l74 -232h2l116 314h26q39 -111 120 -318h2q50 156 69 231
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</svg>Gr-1<sup>high</sup>CD49d<sup>−</sup></td><td align="center">CD11b<sup>+</sup> Ly6G<sup>− </sup>Ly6<svg height="17.012501" id="M2" style="vertical-align:-0.20473pt" version="1.1" viewbox="0 0 39.262501 17.012501" width="39.262501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,16.7)"><path d="M614 175l29 -10q-33 -109 -57 -154q-121 -26 -184 -26q-90 0 -160.5 29t-112.5 77t-63.5 105.5t-21.5 119.5q0 157 108 253t277 96q36 0 71.5 -5t69 -13.5t36.5 -8.5q15 -102 20 -150l-29 -8q-20 79 -66.5 114t-128.5 35q-119 0 -187.5 -86t-68.5 -207
q0 -140 73.5 -227.5t188.5 -87.5q73 0 119.5 37.5t86.5 116.5z" id="x43"></path></g>
<g transform="matrix(.012,0,0,-.012,17.038,8.538)"><path d="M513 0h-211v26q44 5 55 17t11 60v166q0 123 -98 123q-59 0 -104 -51v-238q0 -48 10 -60.5t55 -16.5v-26h-213l1 26q46 4 57 16t11 61v477q0 48 -9.5 58.5t-58.5 14.5v24q63 9 147 35v-336q73 73 143 73q64 0 101 -42t37 -129v-175q0 -49 11 -61t55 -16v-26z" id="x68"></path></g><g transform="matrix(.012,0,0,-.012,23.391,8.538)"><path d="M135 536q-20 0 -35 15.5t-15 35.5q0 22 15 37t36 15t35.5 -15t14.5 -37q0 -21 -15 -36t-36 -15zM252 0h-220v26q48 5 59 17t11 63v206q0 47 -9 58t-54 18v24q78 12 142 39v-345q0 -51 11.5 -63t59.5 -17v-26z" id="x69"></path></g><g transform="matrix(.012,0,0,-.012,26.58,8.538)"><path d="M463 437l5 -8q-21 -38 -45 -51l-57 3q30 -35 30 -88q0 -76 -52.5 -118t-122.5 -42q-24 0 -51 5q-30 -21 -30 -42q0 -16 16 -27t47 -11q19 0 54 0.5t52 0.5q36 0 65.5 -8t53.5 -36t24 -74q0 -77 -75 -137.5t-174 -60.5q-79 0 -126 37.5t-48 84.5q0 32 24 56q21 21 83 70
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</svg>Gr-<svg height="15.8875" id="M3" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 26.200001 15.8875" width="26.200001" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,15.825)"><path d="M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z" id="x31"></path></g>
<g transform="matrix(.012,0,0,-.012,8.225,7.662)"><path d="M135 536q-20 0 -35 15.5t-15 35.5q0 22 15 37t36 15t35.5 -15t14.5 -37q0 -21 -15 -36t-36 -15zM252 0h-220v26q48 5 59 17t11 63v206q0 47 -9 58t-54 18v24q78 12 142 39v-345q0 -51 11.5 -63t59.5 -17v-26z" id="x69"></path></g><g transform="matrix(.012,0,0,-.012,11.414,7.662)"><path d="M524 0h-209v26q44 5 55 18t11 65v167q0 114 -91 114q-50 0 -109 -51v-235q0 -50 10 -61.5t55 -16.5v-26h-217v26q51 5 62 17t11 61v206q0 47 -9.5 58.5t-50.5 19.5v23q82 15 139 40v-79l67 47q47 30 83 30q60 0 94.5 -40t34.5 -112v-193q0 -50 10 -61.5t54 -16.5v-26z
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</svg>CD49d<sup>+</sup></td></tr><tr><td align="left">Human</td><td align="center">MHC class <svg height="16.75" id="M4" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 29.375 16.75" width="29.375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,16.7)"><path d="M303 0h-265v28q62 5 76 19.5t14 77.5v400q0 63 -14 77.5t-76 19.5v28h265v-28q-62 -5 -76 -19.5t-14 -77.5v-400q0 -64 14 -78t76 -19v-28z" id="x49"></path></g><g transform="matrix(.017,0,0,-.017,5.859,16.7)"><path d="M303 0h-265v28q62 5 76 19.5t14 77.5v400q0 63 -14 77.5t-76 19.5v28h265v-28q-62 -5 -76 -19.5t-14 -77.5v-400q0 -64 14 -78t76 -19v-28z" id="x49"></path></g>
<g transform="matrix(.012,0,0,-.012,11.65,8.538)"><path d="M238 0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" id="x6C"></path></g><g transform="matrix(.012,0,0,-.012,14.66,8.538)"><path d="M257 449q92 0 154 -65t62 -158q0 -112 -67 -175t-150 -63q-98 0 -158.5 66.5t-60.5 154.5q0 59 21 106.5t54.5 75.5t71 43t73.5 15zM244 416q-48 0 -81 -47t-33 -128q0 -96 38 -158t99 -62q51 0 82 43.5t31 139.5q0 91 -36 151.5t-100 60.5z" id="x6F"></path></g><g transform="matrix(.012,0,0,-.012,20.55,8.538)"><path d="M696 437v-26q-37 -5 -50.5 -18.5t-28.5 -55.5q-36 -96 -120 -348h-29l-69.5 178.5l-52.5 132.5l-54.5 -141l-64.5 -170h-28q-71 229 -116 357q-13 39 -25.5 49.5t-48.5 15.5v26h207v-26q-45 -7 -53.5 -17t2.5 -44l74 -232h2l116 314h26q39 -111 120 -318h2q50 156 69 231
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</svg>CD33<sup>+</sup>CD11b<sup>+</sup> CD14<sup>−</sup>CD15<sup>+</sup></td><td align="center">MHC class <svg height="16.75" id="M5" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 29.375 16.75" width="29.375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,16.7)"><path d="M303 0h-265v28q62 5 76 19.5t14 77.5v400q0 63 -14 77.5t-76 19.5v28h265v-28q-62 -5 -76 -19.5t-14 -77.5v-400q0 -64 14 -78t76 -19v-28z" id="x49"></path></g><g transform="matrix(.017,0,0,-.017,5.859,16.7)"><path d="M303 0h-265v28q62 5 76 19.5t14 77.5v400q0 63 -14 77.5t-76 19.5v28h265v-28q-62 -5 -76 -19.5t-14 -77.5v-400q0 -64 14 -78t76 -19v-28z" id="x49"></path></g>
<g transform="matrix(.012,0,0,-.012,11.65,8.538)"><path d="M238 0h-223v26q48 5 60 17t12 61v473q0 50 -10.5 60.5t-58.5 15.5v24q73 8 148 35v-608q0 -49 11.5 -61t60.5 -17v-26z" id="x6C"></path></g><g transform="matrix(.012,0,0,-.012,14.66,8.538)"><path d="M257 449q92 0 154 -65t62 -158q0 -112 -67 -175t-150 -63q-98 0 -158.5 66.5t-60.5 154.5q0 59 21 106.5t54.5 75.5t71 43t73.5 15zM244 416q-48 0 -81 -47t-33 -128q0 -96 38 -158t99 -62q51 0 82 43.5t31 139.5q0 91 -36 151.5t-100 60.5z" id="x6F"></path></g><g transform="matrix(.012,0,0,-.012,20.55,8.538)"><path d="M696 437v-26q-37 -5 -50.5 -18.5t-28.5 -55.5q-36 -96 -120 -348h-29l-69.5 178.5l-52.5 132.5l-54.5 -141l-64.5 -170h-28q-71 229 -116 357q-13 39 -25.5 49.5t-48.5 15.5v26h207v-26q-45 -7 -53.5 -17t2.5 -44l74 -232h2l116 314h26q39 -111 120 -318h2q50 156 69 231
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</svg>CD33<sup>+</sup>CD11b<sup>+</sup> CD14<sup>+</sup>CD66b<sup>+</sup></td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Phenotype of monocytic and granulocytic MDSCs subsets in murine and human.

Journal of Immunology Research

tab2

Table 2

Table 2: Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection 