Characterization of Chronic Cutaneous Lesions from TNF-Receptor-1-Deficient Mice Infected by Leishmania major

Table 3

Comparison between human mucocutaneous and TNFR1 KO lesions.

Characteristic	Mucocutaneous leishmaniasis	L. major-infected TNFR1 KO
Chronic cutaneous lesions	Yes	Yes
Intense inflammatory cells infiltrate in chronic phase	Yes	Yes
Low parasite load in lesions	Yes	Yes
High production of proinflammatory cytokines (IFN-γ and TNF-α) in the lesions	Yes	Yes
Defect in the regulation of inflammatory response	Yes	Yes
Presence of high numbers of CD8+ T cells and neutrophils in lesions	Yes	Yes
High levels of IL-17	Yes	Not determined
Invasion of mucosal tissues	Yes	No