Notch Signaling and T-Helper Cells in EAE/MS

Table 2

Notch and animal models of MS.

MS animal model	Method	Results	References
EAE (PLP/SJL)	GSI	↓Disease, ↓Th1	Minter et al., 2005 [10]
EAE (PLP/SJL)	Anti-Notch3	↓Disease, ↓Th1, and ↓Th17	Jurynczyk et al., 2008 [32]
EAE (PLP/SJL)	GSI	↓Disease, ↓Th17	Keerthivasan et al., 2011 [31]
EAE (MOG/B6)	Anti-Dll1	↓Disease, ↓Th1	Elyaman et al., 2007 [35]
TMEV-IDD	Anti-Dll1	↓Disease, ↓IFN-𝛾, and ↓IL-4	Tsugane et al., 2012 [36]
TMEV-IDD	Anti-Dll4	↓Disease, ↓IFN-𝛾, and ↓IL-17	Takeichi et al., 2010 [37]
EAE (PLP/SJL)	Anti-Dll4	↓Disease, ↓Th1, and ↓Th17	Reynolds et al., 2011 [38]
EAE (MOG/B6)	Anti-Dll4	↓Disease, ↓Th1, ↓Th17, ↑Th2, and ↑Treg	Bassil et al., 2011 [13]
EAE (MOG/B6)	Anti-Jagged1	↑Disease, ↓IL-10	Elyaman et al., 2007 [35]
EAE (MOG/B6)	Jagged1 peptide	↓Disease, ↓IFN-𝛾, and ↑IL-4	Palacios et al., 2007 [39]
EAE (MOG/B6)	Anti-Jagged2 signaling molecules prior to immunization	↓Disease, ↑Treg	Elyaman et al., 2012 [21]
	Anti-Jagged2 signaling molecules at time of immunization	↑Disease, ↑IL-17