Dose of Incorporated Immunodominant Antigen in Recombinant BCG Impacts Modestly on Th1 Immune Response and Protective Efficiency against Mycobacterium tuberculosis in Mice

Figure 4

Enhanced protection against M. tb challenge by rBCGs vaccination. Eight weeks after vaccination, mice (𝑛 = 5 or 6) were challenged with M. tb H37Rv; bacillary loads in lung (a) and spleen (b) were determined at 5 weeks after infection and expressed as Log₁₀ CFU per organ. Representative data from one of two experiments were shown. ^∗𝑃<0.05 or ^∗∗𝑃<0.01 (one-way ANOVA).

(a)

(b)