Inhibition of 5-Lipoxygenase Pathway Attenuates Acute Liver Failure by Inhibiting Macrophage Activation
Figure 2
5-LO specific inhibitor AA-861 decreased levels of serum ALT, AST, and Tbil in D-GalN/LPS-treated rats. ((a)–(c)) Compared with experimental groups, the levels of serum ALT, AST, and Tbil in the AA-861 treatment groups were significantly decreased 8 and 24 hr after induction of ALF ().
