Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIV_B’WHU Chronically Infected Chinese Rhesus Macaque

Figure 4

Frequency of naïve and memory CD4⁺ or CD8⁺ T cells in LPS-treated Ch-RMs. CD3⁺CD4⁺ (a) and CD3⁺CD8⁺ (b) T cells were assessed for CD28 and CD95 expression to identify naïve (CD28⁺CD95⁻), central memory (TCM; CD28⁺CD95⁺), and effector memory (TEM; CD28⁻CD95⁺) cell subsets. The percentages of naïve CD8⁺ T cells increased after LPS administration, and effector memory CD8⁺ T cells decreased compared to baseline values. Baseline values were taken prior to LPS administration.

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