Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIV_B’WHU Chronically Infected Chinese Rhesus Macaque

Figure 5

Cytokine profile of CD4⁺ and CD8⁺ T cells in response to PMA and ionomycin stimuli. PBMCs were isolated and stimulated by PMA and ionomycin as described in the Materials and Methods and analyzed by flow cytometry for intracellular production of IFN-γ, TNF-α, IL-2, and IL-4. Proportion of cytokine-producing CD4⁺ T cells in response to stimulus (a); proportion of cytokine-producing CD8⁺ T cells in response to stimulus (b).

(a)

(b)