Adsorption of Toll-Like Receptor 4 Agonist to Alum-Based Tetanus Toxoid Vaccine Dampens Pro-T Helper 2 Activities and Enhances Antibody Responses

Figure 5

Effects of adsorption of LPS onto OVA/TT/alum sensitization on OVA- or TT-induced isotype production. Protocol shown in Figure 4(a). ((a) and (c)) Concentration of OVA-specific isotypes: (a) PCA titers anaphylactic IgE, (b) IgG1, and (c) IgG2a. ((d) and (f)) Concentration of TT-specific isotypes: (d) PCA levels of anaphylactic IgE, (e) IgG1, and (c) IgG2a. Data shown as mean ± SE, one-way ANOVA: ^#; different from OVA/TT/alum/PBS group (), and experiment was repeated twice.

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