Research Article
Preexisting Antibodies to an F(ab′)2 Antibody Therapeutic and Novel Method for Immunogenicity Assessment
Figure 5
Response-time plots of ATA titer to the whole F(ab′)2 molecule and anti-CDR ATA positivity status by dose group. Solid light gray bar: pretreatment titer (average of two samples). Solid blue bar: posttreatment titer for anti-CDR negative sample. Horizontal hatched red: posttreatment titer for anti-CDR positive sample. Diagonal hatched yellow bar: posttreatment titer for anti-CDR indeterminate sample.
| (a) Control group |
| (b) 5 mg/kg dose group |
| (c) 15 mg/kg dose group |
| (d) 50 mg/kg dose group |