Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

Table 4

Genotypic distribution of TLR3 gene polymorphisms when chronic HCV patients were compared to patients diagnosed with liver cirrhosis.

SNPs	Genotype/allele distribution	Chronic HCV	Liver cirrhosis	OR (95% C.I.)		value
		rs5743311	AA				0 (0%)	0 (0%)	4.829 (0.095–244.994)	NaN	1.00
AG	15 (3.43%)		1 (1.14%)	0.323 (0.042–2.480)	1.31	0.253
GG	422 (96.57%)		87 (98.86%)	Ref
A	15 (1.72%)		1 (0.57%)	0.327 (0.043–2.494)	1.29	0.515
G	859 (98.28%)		175 (99.43%)
AA+AG.VS.GG				0.323 (0.042–2.480)	1.31	0.253
AA.VS.AG+GG				0.202 (0.004–10.263)	NaN	1.00
rs5743312	TT	15 (3.43%)	1 (1.14%)	0.301 (0.039–2.321)	1.49	0.223
	CT	110 (25.17%)	18 (20.45%)	0.740 (0.422–1.299)	1.11	0.292
	CC	312 (71.4%)	69 (78.41%)	Ref
	T	140 (16.02%)	20 (11.36%)	0.672 (0.408–1.108)	2.46	0.117
	C	734 (83.98%)	156 (88.64%)
	TT+CT.VS.CC			0.687 (0.397–1.190)	1.81	0.178
	TT.VS.CT+CC			3.092 (0.403–23.720)	1.31	0.253
rs1879026	TT	13 (2.97%)	2 (2.27%)	0.698 (0.154–3.169)	0.22	0.639
	GT	129 (29.52%)	21 (23.86%)	0.739 (0.433–1.260)	1.24	0.265
	GG	295 (67.51%)	65 (73.86%)	Ref
	T	155 (17.73%)	25 (14.2%)	0.768 (0.486–1.213)	1.29	0.257
	G	719 (82.27%)	151 (85.8%)
	TT+GT.VS.GG			0.735 (0.439–1.231)	1.37	0.241
	TT.VS.GT+GG			1.318 (0.292–5.948)	0.13	0.718
rs5743313	TT	28 (6.41%)	8 (9.09%)	1.825 (0.772–4.317)	1.92	0.165
	CT	179 (40.96%)	44 (50%)	1.570 (0.970–2.543)	3.40	0.065
	CC	230 (52.63%)	36 (40.91%)	Ref
	T	235 (26.89%)	60 (34.09%)	1.406 (0.995–1.987)	3.76	0.052
	C	639 (73.11%)	116 (65.91%)
	TT+CT.VS.CC			1.605 (1.009–2.554)	4.03	0.045
	TT.VS.CT+CC			0.685 (0.301–1.557)	0.83	0.363
rs5743314	CC	28 (6.41%)	8 (9.09%)	1.902 (0.803–4.505)	2.19	0.138
	GC	176 (40.27%)	45 (51.14%)	1.702 (1.050–2.759)	4.72	0.029
	GG	233 (53.32%)	35 (39.77%)	Ref
	C	232 (26.54%)	61 (34.66%)	1.468 (1.040–2.072)	4.79	0.03
	G	642 (73.46%)	115 (65.34%)
	CC+GC.VS.GG			1.730 (1.085–2.757)	5.38	0.0204
	CC.VS.GC+GG			0.685 (0.301–1.557)	0.83	0.363
rs5743315	AA	3 (0.69%)	0 (0%)	0.694 (0.035–13.585)	0.61	0.434
	AC	92 (21.05%)	18 (20.45%)	0.956 (0.542–1.685)	0.02	0.876
	CC	342 (78.26%)	70 (79.55%)	Ref
	A	98 (11.21%)	18 (10.23%)	0.902 (0.530–1.534)	0.14	0.703
	C	776 (88.79%)	158 (89.77%)
	AA+AC.VS.CC			0.926 (0.526–1.630)	0.07	0.789
	AA.VS.AC+CC			1.426 (0.073–27.846)	0.61	0.436
rs111611328	CC	0 (0%)	0 (0%)	5.023 (0.099–254.873)	NaN	1.00
	GC	3 (0.69%)	2 (2.27%)	3.364 (0.554–20.436)	1.95	0.162
	GG	434 (99.31%)	86 (97.73%)	Ref
	C	3 (0.34%)	2 (1.14%)	3.337 (0.554–20.120)	1.94	0.468
	G	871 (99.66%)	174 (98.86%)
	CC+GC.VS.GG			3.364 (0.554–20.436)	1.95	0.126
	CC.VS.GC+GG			0.202 (0.004–10.263)	NaN	1.00
rs78726532	GG	3 (0.69%)	0 (0%)	0.671 (0.034–13.130)	0.63	0.426
	AG	94 (21.51%)	16 (18.18%)	0.804 (1.447–1.447)	0.53	0.466
	AA	340 (77.8%)	72 (81.82%)	Ref
	G	100 (11.44%)	16 (9.09%)	0.774 (0.445–1.348)	0.82	0.364
	A	774 (88.56%)	160 (90.91%)
	GG+AG.VS.AA			0.779 (0.433–1.401)	0.7	0.403
	GG.VS.AG+AA			1.426 (0.073–27.846)	0.61	0.436