Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection

Table 5

Genotypic distribution of TLR3 gene polymorphisms when chronic HCV patients were compared to patients diagnosed with liver cirrhosis and HCC.

SNPs	Genotype/allele distribution	Chronic HCV	Cirrhosis + HCC	OR (95% C.I.)		value
		rs5743311	AA				0 (0%)	0 (0%)	3.421 (0.068–173.296)	NaN	1.00
AG	15 (3.43%)		3 (2.38%)	0.686 (0.195–2.409)	0.35	0.554
GG	422 (96.57%)		123 (97.62%)	Ref
A	15 (1.72%)		3 (1.19%)	0.690 (0.198–2.402)	0.34	0.779
G	859 (98.28%)		249 (98.81%)
AA+AG.VS.GG				0.686 (0.195–2.409)	0.35	0.554
AA.VS.AG+GG				0.289 (0.006–14.645)	NaN	1.00
rs5743312	TT	15 (3.43%)	1 (0.79%)	0.217 (0.028–1.662)	2.61	0.106
	CT	110 (25.17%)	29 (23.02%)	0.857 (0.536–1.369)	0.42	0.517
	CC	312 (71.4%)	96 (76.19%)	Ref
	T	140 (16.02%)	31 (12.3%)	0.735 (0.485–1.116)	2.1	0.147
	C	734 (83.98%)	221 (87.7%)
	TT+CT.VS.CC			0.780 (0.493–1.235)	1.13	0.288
	TT.VS.CT+CC			4.43 (0.581–33.968)	2.47	0.116
rs1879026	TT	13 (2.97%)	2 (1.59%)	0.493 (0.109–2.226)	0.88	0.348
	GT	129 (29.52%)	32 (25.4%)	0.795 (0.506–1.250)	0.99	0.321
	GG	295 (67.51%)	92 (73.02%)	Ref
	T	155 (17.73%)	36 (14.29%)	0.773 (0.522–1.146)	1.65	0.198
	G	719 (82.27%)	216 (85.71%)
	TT+GT.VS.GG			0.768 (0.494–1.194)	1.38	0.239
	TT.VS.GT+GG			1.901 (0.423–8.537)	0.73	0.394
rs5743313	TT	28 (6.41%)	9 (7.14%)	1.369 (0.611–3.069)	0.59	0.444
	CT	179 (40.96%)	63 (50%)	1.499 (0.992–2.265)	3.72	0.054
	CC	230 (52.63%)	54 (42.86%)	Ref
	T	235 (26.89%)	81 (32.14%)	1.288 (0.951–1.745)	2.68	0.102
	C	639 (73.11%)	171 (67.86%)
	TT+CT.VS.CC			1.481 (0.993–2.209)	3.74	0.053
	TT.VS.CT+CC			0.890 (0.409–1.939)	0.09	0.769
rs5743314	CC	28 (6.41%)	9 (7.14%)	1.387 (0.619–3.109)	0.64	0.425
	GC	176 (40.27%)	63 (50%)	1.545 (1.022–2.334)	4.29	0.0383
	GG	233 (53.32%)	54 (42.86%)	Ref
	C	232 (26.54%)	81 (32.14%)	1.311 (0.967–1.777)	3.05	0.0805
	G	642 (73.46%)	171 (67.86%)
	CC+GC.VS.GG			1.523 (1.021–2.271)	4.28	0.0385
	CC.VS.GC+GG			0.890 (0.409–1.939)	0.09	0.769
rs5743315	AA	3 (0.69%)	0 (0%)	0.487 (0.025–9.504)	0.88	0.349
	AC	92 (21.05%)	26 (20.63%)	0.967 (0.593–1.576)	0.02	0.891
	CC	342 (78.26%)	100 (79.37%)	Ref
	A	98 (11.21%)	26 (10.32%)	0.911 (0.577–1.439)	0.16	0.689
	C	776 (88.79%)	226 (89.68%)
	AA+AC.VS.CC			0.936 (0.575–1.524)	0.07	0.7903
	AA.VS.AC+CC			2.038 (0.105–39.716)	0.87	0.351
rs111611328	CC	0 (0%)	1 (0.79%)	10.555 (0.427–260.710)	3.51	0.061
	GC	3 (0.69%)	2 (1.59%)	2.352 (0.389–14.236)	0.92	0.337
	GG	434 (99.31%)	123 (97.62%)	Ref
	C	3 (0.34%)	4 (1.59%)	4.683 (1.041–21.062)	4.9	0.088
	G	871 (99.66%)	248 (98.41%)
	CC+GC.VS.GG			3.528 (0.703–17.701)	2.66	0.103
	CC.VS.GC+GG			0.096 (0.004–2.362)	3.47	0.062
rs78726532	GG	3 (0.69%)	0 (0%)	0.475 (0.024–9.263)	0.90	0.343
	AG	94 (21.51%)	24 (19.05%)	0.851 (0.516–1.403)	0.4	0.526
	AA	340 (77.8%)	102 (80.95%)	Ref
	G	100 (11.44%)	24 (9.52%)	0.815 (0.510–1.303)	0.73	0.392
	A	774 (88.56%)	228 (90.48%)
	GG+AG.VS.AA			0.825 (0.501–1.358)	0.57	0.448
	GG.VS.AG+AA			2.038 (0.105–39.716)	0.87	0.351