HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined

Table 7

Fifteen HLA class II DQβ epitopes and three DQα epitopes defined.

Epitope number^a	DQ antigens sharing epitope	Position/amino acid^b
2001	DQB2	28S/30S/37I/52L/55L
2002	DQB4	56L
2003	DQB4, DQB5, DQB6, DQB7, DQB8, DQB9	28T/46V/52P
2004	DQB5, DQB6	84E/85V/86A/89G/90I/221Q
2005	DQB7	45E
2006	DQB7, DQB8, DQB9	55P
2007	DQB4, DQB5, DQB6	52P + 55R
2008	DQB2, DQB5, DQB7, DQB8, DQB9	(9Y + 11F)
2009	DQB2, DQB4, DQB5, DQB6, DQB8, DQB9	34R + 45G
2010	DQB4, DQB5, DQB6, DQB8, DQB9	45G + 46V
2011	DQB5, DQB0601	38V + 46V
2012	DQB8, DQB9	45G + 55P
2013	DQB2, DQB4, DQB7, DQB8, DQB9	84Q/85L/86E/87L/89T/220H/221H
2014	DQB4, DQB7, DQB8, DQB9	77T + 84Q/77T + 85L/77T + 86E/77T + 87L/182N
2015	DQB5	70G + 71A/116I/125S
2017	DQA1*0201	47K/52H/54L
2018	DQA1*04/DQA1*05/DQA1*06	40G/47C
2019	DQA1*03	26S/47Q/56R/187T

^aEpitope 2008 defined using mAb; ^bpossible alternative epitopes are separated by “/”; epitopes that are defined by more than a single position/aa are separated by “+”; amino acids not exposed at the surface of the HLA molecule are between parentheses.