Genetics and Molecular Biology of Epstein-Barr Virus-Encoded BART MicroRNA: A Paradigm for Viral Modulation of Host Immune Response Genes and Genome Stability

Figure 2

A region within the EBV BART microRNA encoding BamHI A fragment contains regulatory sequences for multiple EBV- and host-encoded immune response transcription factors. EBV genome sequences 164,810 to 164,970 are shown in inverted orientation, with sites for BART also indicated. Sites resembling consensus response elements for CREB, AP-1, and SP1 and a putative TATA box have been identified in the EBV BamHI fragment also encoding BART. AP-1 sites resemble binding sites for host fos/jun factors are similar to sites recognized by the EBV-encoded BZLF-1 (ZEBRA) transcription factor (see text).