Genetics and Molecular Biology of Epstein-Barr Virus-Encoded BART MicroRNA: A Paradigm for Viral Modulation of Host Immune Response Genes and Genome Stability

Table 2

Central role of BART and host transcription factor NF-κB in regulation of host and EBV shared immune response genes (summary).

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(i) EBV BARF (BamHI A right frame) encodes multiple viral microRNAs (BamHI A fragment right transcripts) that are important for viral latency and immune evasion.

(ii) Viral LMP-2A, host NF-κB(+) positive regulator of BART, and resistance to apoptosis reversed by viral ZEBRA (BZLF-1) lytic protein.

(iii) BART are transferred to bystander cells by unknown
mechanisms, possibly vesicles or defective viral particles.

(iv) Other EBV mRNAs may be transferred with BART microRNA to bystander cells by unknown mechanisms.

(v) Potential for multiple viral regulatory interactions with host and bystanders cell microRNA and gene transcription
networks is important in immune surveillance, cell growth, and genome stability.

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