Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro

Figure 1

IFN-α pretreatment inhibits HBV infection. Differentiated HepaRG cells were treated with 1000 IU/mL of IFN-α for 1 day (IFN-a(−1)) and then infected with HBV (MOI = 200) (a). HBeAg from cell culture supernatant was measured by ELISA at day 10 (b). HBsAg was measured at day 7 and day 10 (c). HBV cccDNA and intracellular DNA were evaluated by qPCR (d). HBV core was detected by Western blot (e). Data are means ± s.d. , , and by Student’s unpaired two-tailed -test.

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