Immunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions

Figure 2

HE sections of drug-induced hypersensitivity syndrome/exanthema in drug reaction with eosinophilia and systemic syndrome. Two cases that are associated with liver function deficiency show different histopathologies: intermittent interface change, few necrotic keratinocytes, and slight spongiosis in (a); diffuse interface change, several necrotic keratinocytes, and considerable spongiosis with spongiotic bullae in (b). Bar = 100 μm.

(a)

(b)